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Ispinesib

Go to external page http://purl.obolibrary.org/obo/NCIT_C38131

A synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. [ ]

Term info

Label

Ispinesib

Synonyms
  • CK0238273
  • ISPINESIB
  • Ispinesib
  • SB-715992
  • ispinesib
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of cancer. Ispinesib blocks a protein that tumor cells need to divide. It is a type of mitotic inhibitor.

CAS Registry

336113-53-2

Chemical Formula

C30H33ClN4O2

Display Name

Ispinesib

FDA UNII Code

BKT5F9C2NI

Has Salt Form

http://purl.obolibrary.org/obo/NCIT_C77518

Has Target

http://purl.obolibrary.org/obo/NCIT_C48872

NSC Code

727990

Preferred Name

Ispinesib

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1527260

code

C38131