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Alvespimycin

Go to external page http://purl.obolibrary.org/obo/NCIT_C38142

An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. [ ]

Term info

Label

Alvespimycin

Synonyms
  • 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin
  • 17-DMAG
  • 17-dimethylaminoethylamino-17-demethoxygeldanamycin
  • ALVESPIMYCIN
  • Alvespimycin
  • Geldanamycin,17-demethoxy-17-((2-(dimethylamino)ethyl)amino)-
Subsets

NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C157712

ALT DEFINITION

17-DMAG. A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called geldanamycin analogs.

CAS Registry

467214-20-6

Chemical Formula

C32H48N4O8

FDA UNII Code

001L2FE0M3

Has Salt Form

http://purl.obolibrary.org/obo/NCIT_C76665

Has Target

http://purl.obolibrary.org/obo/NCIT_C17766

Legacy Concept Name

_17-Dimethylaminoethylamino_17-Demethoxygeldanamycin

NSC Code

707545

Preferred Name

Alvespimycin

Semantic Type

Pharmacologic Substance, Antibiotic, Organic Chemical

UMLS CUI

C1527262

code

C38142