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Melanocyte Protein PMEL

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Melanocyte protein PMEL (661 aa, ~70 kDa) is encoded by the human PMEL gene. This protein plays a role in melanogenesis. [ ]

Term info

Label

Melanocyte Protein PMEL

Synonyms
  • 95 kDa Melanocyte-Specific Secreted Glycoprotein
  • ME20
  • ME20-M
  • ME20-M/ME20-S
  • ME20M
  • ME20M/ME20S
  • Melanocyte Lineage-Specific Antigen gp100
  • Melanocyte Protein 17
  • Melanocyte Protein MEL17
  • Melanocyte Protein Mel 17
  • Melanocyte Protein PMEL
  • Melanocyte Protein PMEL17
  • Melanocyte Protein Pmel 17
  • Melanocytes Lineage-Specific Antigen gp100
  • Melanoma-Associated ME20 Antigen
  • Melanosomal Matrix Protein17
  • P1
  • P100
  • PMEL
  • PMEL17
  • Premelanosome Protein
  • SI
  • SIL
  • SILV
  • Silver Homolog
  • Silver Like
  • Silver Locus Protein Homolog
  • gp100
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Melanocyte protein PMEL can be glycosylated and cleaved forming a disulfide linked dimer comprised of a large lumenal subunit, M-alpha (ME20-S; 95 kDa melanocyte-specific secreted glycoprotein; P26; secreted melanoma-associated ME20 antigen; ME20-S; ME20S) and an integral membrane subunit, M-beta. A fraction of the M-alpha is secreted and can be further processed. (UniProt)

Display Name

Melanocyte Protein PMEL

Legacy Concept Name

Melanocyte_Lineage-Specific_Antigen-gp100

OMIM Number

155550

Preferred Name

Melanocyte Protein PMEL

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

P40967

UMLS CUI

C0257766

code

C41037