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Protein Kinase B

Go to external page http://purl.obolibrary.org/obo/NCIT_C41625

Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. [ ]

Term info

Label

Protein Kinase B

Synonyms
  • AKT
  • Akt
  • Protein Kinase B
  • protein kinase B
ALT DEFINITION

A group of enzymes involved in several processes related to cell growth and survival. Protein kinase B enzymes help to transfer signals inside cells. A protein kinase B enzyme is a type of serine/threonine protein kinase.

Legacy Concept Name

Protein_Kinase_B

Preferred Name

Protein Kinase B

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

UMLS CUI

C0164786

code

C41625