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Programmed Cell Death 1 Ligand 2

Go to external page http://purl.obolibrary.org/obo/NCIT_C45438

Programmed cell death 1 ligand 2 (273 aa, ~31 kDa) is encoded by the human PDCD1LG2 gene. This protein is involved in the modulation of both T-cell proliferation and cytokine production. [ ]

Term info

Label

Programmed Cell Death 1 Ligand 2

Synonyms
  • B7 Dendritic Cell Molecule
  • B7-DC
  • B7DC
  • Butyrophilin B7-DC
  • CD273
  • CD273 Antigen
  • PD-1 Ligand 2
  • PD-1-Ligand 2
  • PD-L2
  • PD1 Ligand 2 Protein
  • PDCD1 Ligand 2
  • PDCD1 Ligand 2 Protein
  • PDCD1L2
  • PDCD1LG2
  • PDL2
  • Programmed Cell Death 1 Ligand 2
  • Programmed Death Ligand 2
  • Programmed Death Ligand 2 Protein
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Widely expressed (highest in placenta, heart, pancreas, lung, and liver) by human PDCD1LG2 Gene, 273 aa 31-kDa Programmed Death Ligand 2 Protein is 70% identical to mouse Pdl2 protein and contains a signal sequence, IgV- and IgC-like domains, a transmembrane region, and a cytoplasmic region. Gamma-interferon stimulates PDCD1LG2 expression in monocytes. The IgV domain appears to bind to PDCD1, but not to CTLA4, CD28, or ICOS. Stimulation with anti-CD3 and Pdl2, or Pdl1, inhibits proliferation of mouse T cells and cytokine production. At low anti-CD3 concentrations, mouse Pdl2 preferentially co-stimulates CD4-positive (Th1) T-cell proliferation and Ifng production.

Display Name

Programmed Cell Death 1 Ligand 2

Legacy Concept Name

Programmed_Death_Ligand-2_Protein

OMIM Number

605723

Preferred Name

Programmed Cell Death 1 Ligand 2

Semantic Type

Amino Acid, Peptide, or Protein

Swiss Prot

Q9BQ51

UMLS CUI

C0965743

code

C45438