CYP2C9*3 Allele
Human CYP2C9*3 allele is located within 10q24 and is approximately 33 kb in length. This allele, a variant form of the CYP2C9 wild-type allele, encodes cytochrome P450 2C9*3 protein. The CYP2C9*3 allele exhibits a clinically-relevant SNP (c.1075A>C) in exon 7 that results in an I359L coding change. This alteration in protein sequence decreases the enzymatic activity of the cytochrome P450 2C9*3 protein. [ ]
Term info
CYP2C9*3 Allele
- CYP2C9*3
- CYP2C9*3 Allele
- CYP2C9, I359L
- CYP2C9, c.1075A>C
- Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*3 Allele
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
Ethnicity Association: African American; Asian; Black African; Caucasian
CYP2C9*3 Allele
NM_000771
Cytochrome P450 2C9
CYP2C9_3_Allele
601130
CYP2C9*3 Allele
11503012, 15608560
rs1057910
Gene or Genome
C1707203
C45614
Term relations
- CYP2C9 Gene
- Allele_Plays_Altered_Role_In_Process some Drug Metabolism
- Allele_Has_Abnormality some Adenosine to Cytosine Transversion Abnormality
- Allele_Plays_Altered_Role_In_Process some Xenobiotic Metabolism
- Allele_Has_Abnormality some Transversion Mutation
- Allele_Has_Activity some Decreased Biochemical Activity
- Allele_In_Chromosomal_Location some 10q24