Human CYP2C9*5 allele is located within 10q24 and is approximately 33 kb in length. This allele, a variant form of the CYP2C9 wild-type allele, encodes cytochrome P450 2C9*5 protein. The CYP2C9*5 allele exhibits a clinically-relevant SNP (c.1080C>G) in exon 7 that results in a D360E coding change. This alteration in the cytochrome P450 2C9*5 protein sequence increases the Km of this enzyme for (S)-warfarin, diclofenac, and lauric acid, thereby decreasing clearance of these drugs. [ ]