CYP2D6*10 Allele
Human CYP2D6*10 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*10 protein. The CYP2D6*10 allele exhibits a clinically-relevant SNP (g.100C>T) that results in a P34S coding change. This alteration decreases the enzymatic activity of the cytochrome P450 2D6*10 protein. [ ]
Term info
CYP2D6*10 Allele
- CYP2D6*10
- CYP2D6*10 Allele
- CYP2D6, P34S
- CYP2D6, g.100C>T
- CYP2D6J
- Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*10 Allele
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
Ethnicity Association: Asian; African American; Black African; Caucasian; Middle Eastern
CYP2D6*10 Allele
NM_000106
Cytochrome P450 2D6
CYP2D6_10_Allele
124030
CYP2D6*10 Allele
7935325, 8287064
Gene or Genome
C1706118
C45617
Term relations
- CYP2D6 Gene
- Allele_Plays_Altered_Role_In_Process some Drug Metabolism
- Allele_In_Chromosomal_Location some 22q13.1
- Allele_Plays_Altered_Role_In_Process some Xenobiotic Metabolism
- Allele_Has_Abnormality some Cytosine to Thymidine Transition Abnormality
- Allele_Has_Activity some Decreased Biochemical Activity
- Allele_Has_Abnormality some Transition Mutation