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CYP3A4*17 Allele

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Human CYP3A4*17 allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, a variant form of the CYP3A4 wild-type allele, encodes cytochrome P450 3A4*17 protein. The CYP3A4*17 allele exhibits a clinically-relevant SNP (g.15615T>C) in exon 7 that results in a F189S coding change. This alteration in protein sequence severely decreases the enzymatic activity of the cytochrome P450 3A4*17 protein. [ ]

Term info

Label

CYP3A4*17 Allele

Synonyms
  • CYP3A4*17
  • CYP3A4*17 Allele
  • CYP3A4, F189S
  • CYP3A4, g.15615T>C
  • Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*17 Allele
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Ethnicity Association: Asian

Display Name

CYP3A4*17 Allele

Gene Encodes Product

Cytochrome P450 3A4

Legacy Concept Name

CYP3A4_17_Allele

OMIM Number

124010

Preferred Name

CYP3A4*17 Allele

SNP ID

rs4987161

Semantic Type

Gene or Genome

UMLS CUI

C1707234

code

C46026