CYP3A4*18 Allele
Human CYP3A4*18 allele is located in the vicinity of 7q21.1 and is approximately 27 kb in length. This allele, a variant form of the CYP3A4 wild-type allele, encodes cytochrome P450 3A4*18 protein. The CYP3A4*18 allele exhibits a clinically-relevant SNP (g.20070T>C) in exon 10 that results in a L293P coding change. This alteration in protein sequence dramatically increases the enzymatic activity of the cytochrome P450 3A4*18 protein. [ ]
Term info
CYP3A4*18 Allele
- CYP3A4*18
- CYP3A4*18 Allele
- CYP3A4, L293P
- CYP3A4, g.20070T>C
- Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*18 Allele
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
Ethnicity Association: Caucasian
CYP3A4*18 Allele
Cytochrome P450 3A4
CYP3A4_18_Allele
124010
CYP3A4*18 Allele
11714865
Gene or Genome
C1707235
C46027
Term relations
- CYP3A4 Gene
- Allele_Plays_Altered_Role_In_Process some Drug Metabolism
- Allele_Plays_Altered_Role_In_Process some Xenobiotic Metabolism
- Allele_In_Chromosomal_Location some 7q22.1
- Allele_Has_Activity some Enhanced Biochemical Activity
- Allele_Has_Abnormality some Transition Mutation
- Allele_Has_Abnormality some Thymidine to Cytosine Transition Abnormality