Terminology Service for NFDI4Health

CYP2C8*2 Allele

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Human CYP2C8*2 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*2 protein. The CYP2C8*2 allele exhibits a clinically-relevant SNP (c.805A>T) in exon 5 that results in an I269F coding change. This sequence alteration in the cytochrome P450 2C8*2 protein increases the Km of this enzyme for paclitaxel, thereby decreasing the clearance of this drug. [ ]

Term info

Label

CYP2C8*2 Allele

Synonyms
  • CYP2C8*2
  • CYP2C8*2 Allele
  • CYP2C8, I269F
  • CYP2C8, c.805A>T
  • Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*2 Allele
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Ethnicity Association: African American

Display Name

CYP2C8*2 Allele

Gene Encodes Product

Cytochrome P450 2C8

Legacy Concept Name

CYP2C8_2_Allele

OMIM Number

601129

Preferred Name

CYP2C8*2 Allele

SNP ID

rs11572103

Semantic Type

Gene or Genome

UMLS CUI

C1707189

code

C46030