CYP1A2*1 Allele
Human CYP1A2*1 allele is located within 15q24 and is approximately 8 kb in length. This allele, a variant form of the CYP1A2 wild-type allele, encodes cytochrome P450 1A2*1 protein. There are multiple haplotypes of the CYP1A2*1 allele. Both CYP1A2*1C, which has a SNP (g.-3860G>A) in the 5' flanking region of the gene, and CYP1A2*1K, which has a SNP (g.-729C>T) in intron 1, encode cytochrome P450 1A2*1 proteins that exhibit decreased in vivo enzymatic activity. CYP1A2*1F exhibits a SNP (g.-163C>A) in intron 1 that has been linked with higher enzyme inducibility. [ ]
Term info
CYP1A2*1 Allele
- CYP1A2*1
- CYP1A2*1 Allele
- CYP1A2, g.-3860G>A, g.-729C>T, g.-163C>A
- CYP1A2, wild-type
- Cytochrome P450, Family 1, Subfamily A, Polypeptide 2*1 Allele
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
CYP1A2*1 Allele
NM_000761
Cytochrome P450 1A2
CYP1A2_1_Allele
124060
CYP1A2*1 Allele
12920202, 10101295
Gene or Genome
C1707174
C46037
Term relations
- CYP1A2 Gene
- Allele_Plays_Altered_Role_In_Process some Drug Metabolism
- Allele_Plays_Altered_Role_In_Process some Xenobiotic Metabolism
- Allele_Has_Abnormality some Guanosine to Adenosine Transition Abnormality
- Allele_Has_Abnormality some Transversion Mutation
- Allele_Has_Abnormality some Cytosine to Adenosine Transversion Abnormality
- Allele_Has_Activity some Decreased Biochemical Activity
- Allele_In_Chromosomal_Location some 15q24
- Allele_Has_Abnormality some Transition Mutation