Human CYP2D6*15 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*15 protein. The CYP2D6*15 allele exhibits a single nucleotide insertion (g.138insT) in exon 1 that causes in a frameshift during coding. This alteration abolishes the enzymatic activity of the cytochrome P450 2D6*15 protein. [ ]