Terminology Service for NFDI4Health
JSON

CYP2D6*18 Allele

Go to external page http://purl.obolibrary.org/obo/NCIT_C46050

Human CYP2D6*18 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*18 protein. The CYP2D6*18 allele exhibits a nine nucleotide insertion (g.4125insGTGCCCACT) in exon 9. This alteration increased the Km value of the cytochrome P450 2D6*18 protein toward bufuralol, resulting in decreased enzymatic activity. [ ]

Term info

Label

CYP2D6*18 Allele

Synonyms
  • CYP2D6(J9)
  • CYP2D6*18
  • CYP2D6*18 Allele
  • CYP2D6, g.4125insGTGCCCACT
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*18 Allele
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Ethnicity Association: Asian

Display Name

CYP2D6*18 Allele

Gene Encodes Product

Cytochrome P450 2D6

Legacy Concept Name

CYP2D6_18_Allele

OMIM Number

124030

Preferred Name

CYP2D6*18 Allele

Semantic Type

Gene or Genome

UMLS CUI

C1707214

code

C46050