CYP2D6*35X2 Allele
Human CYP2D6*35X2 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, an amplification variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*35 protein. The CYP2D6*35 allele exhibits four SNPs (g.31G>A; g.1661G>C; g.2850C>T; g.4180G>C) that result in three coding changes (V11M; R296C; S486T). The CYP2D6*35X2 allele has two copies of the CYP2D6*35 allelic variant. This duplication increases the enzymatic activity of the cytochrome P450 2D6*35 protein in subjects who carry this allele. [ ]
Term info
CYP2D6*35X2 Allele
- CYP2D6*35X2
- CYP2D6*35X2 Allele
- Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*35X2 Allele
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
Ethnicity Association: Caucasian
CYP2D6*35X2 Allele
NM_000106
Cytochrome P450 2D6
CYP2D6_35X2_Allele
124030
CYP2D6*35X2 Allele
9511177
Gene or Genome
C1707220
C46054
Term relations
- CYP2D6 Gene
- Allele_Plays_Altered_Role_In_Process some Drug Metabolism
- Allele_In_Chromosomal_Location some 22q13.1
- Allele_Plays_Altered_Role_In_Process some Xenobiotic Metabolism
- Allele_Has_Abnormality some Multiple Transversion Abnormalities
- Allele_Has_Activity some Enhanced Biochemical Activity
- Allele_Has_Abnormality some Multiple Transition Abnormalities