CYP2D6*41 Allele
Human CYP2D6*41 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*41 protein. The CYP2D6*41 allele exhibits clinically-relevant SNPs (g.2850C>T; g.4180G>C) in exons 6 and 9 that result in R296C and S486T coding changes. These alterations in protein sequence decrease the enzymatic activity of the cytochrome P450 2D6*41 protein. [ ]
Term info
CYP2D6*41 Allele
- CYP2D6*41
- CYP2D6*41 Allele
- CYP2D6, R296C, S486T
- CYP2D6, g.2850C>T, g.4180G>C
- Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*41 Allele
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
Ethnicity Association: African American; Caucasian
CYP2D6*41 Allele
NM_000106
Cytochrome P450 2D6
CYP2D6_41_Allele
124030
CYP2D6*41 Allele
15289790, 15768052, 11037799
Gene or Genome
C1705362
C46058
Term relations
- CYP2D6 Gene
- Allele_Plays_Altered_Role_In_Process some Drug Metabolism
- Allele_In_Chromosomal_Location some 22q13.1
- Allele_Plays_Altered_Role_In_Process some Xenobiotic Metabolism
- Allele_Has_Abnormality some Cytosine to Thymidine Transition Abnormality
- Allele_Has_Abnormality some Transversion Mutation
- Allele_Has_Activity some Decreased Biochemical Activity
- Allele_Has_Abnormality some Guanosine to Cytosine Transversion Abnormality
- Allele_Has_Abnormality some Transition Mutation