CYP2D6*42 Allele
Human CYP2D6*42 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*42 protein. The CYP2D6*42 allele exhibits a two nucleotide insertion (g.3259insGT) that results in a frameshift during protein coding. This alteration abolishes the enzymatic activity of the cytochrome P450 2D6*42 protein. [ ]
Term info
CYP2D6*42 Allele
- CYP2D6*42
- CYP2D6*42 Allele
- CYP2D6, g.3259insGT
- Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*42 Allele
NCIT_C116977, NCIT_C142800, NCIT_C142799
CTRP
Ethnicity Association: African American
CYP2D6*42 Allele
NM_000106
CYP2D6_42_Allele
124030
CYP2D6*42 Allele
Gene or Genome
C1707224
C46059
Term relations
- CYP2D6 Gene
- Allele_Has_Abnormality some Frameshift Mutation
- Allele_Plays_Altered_Role_In_Process some Drug Metabolism
- Allele_In_Chromosomal_Location some 22q13.1
- Allele_Plays_Altered_Role_In_Process some Xenobiotic Metabolism
- Allele_Has_Abnormality some Insertion Mutation
- Allele_Has_Activity some Absence of Biochemical Activity