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Cediranib Maleate

Go to external page http://purl.obolibrary.org/obo/NCIT_C48379

The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGFR-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth. [ ]

Term info

Label

Cediranib Maleate

Synonyms
  • AZD2171
  • AZD2171 Maleate
  • CEDIRANIB MALEATE
  • Cediranib Maleate
  • Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-
  • Recentin
  • cediranib maleate
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of some types of cancer. Cediranib maleate may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor.

CAS Registry

857036-77-2

Chemical Formula

C25H27FN4O3.C4H4O4

Display Name

Cediranib Maleate

FDA UNII Code

68AYS9A614

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C80867

Has Target

http://purl.obolibrary.org/obo/NCIT_C26202, http://purl.obolibrary.org/obo/NCIT_C26203, http://purl.obolibrary.org/obo/NCIT_C17975, http://purl.obolibrary.org/obo/NCIT_C28496

NSC Code

732208

Preferred Name

Cediranib Maleate

Semantic Type

Pharmacologic Substance

UMLS CUI

C1541530

code

C48379