Terminology Service for NFDI4Health
JSON

7,8-Dihydro-8-Oxoguanine Triphosphatase

Go to external page http://purl.obolibrary.org/obo/NCIT_C49206

7,8-dihydro-8-oxoguanine triphosphatase (197 aa, ~23 kDa) is encoded by the human NUDT1 gene. This protein is involved in the metabolism of both dGTP and DNA. [ ]

Term info

Label

7,8-Dihydro-8-Oxoguanine Triphosphatase

Synonyms
  • 2-Hydroxy-dATP Diphosphatase
  • 7,8-Dihydro-8-Oxoguanine Triphosphatase
  • 8-oxo-dGTPase
  • EC 3.6.1.55
  • EC 3.6.1.56
  • Nucleoside Diphosphate-Linked Moiety X Motif 1
  • Nudix Motif 1
DesignNote

7,8-dihydro-8-oxoguanine triphosphatase catalyzes the hydrolysis of 8-oxo-dGTP to yield 8-oxo-dGMP and diphosphate. Misincorporation of 8-oxo-dGTP into DNA can result in A:T to C:G transversion mutations.

Legacy Concept Name

Eight-oxo-dGTPase

OMIM Number

600312

Preferred Name

7,8-Dihydro-8-Oxoguanine Triphosphatase

Semantic Type

Amino Acid, Peptide, or Protein, Enzyme

Swiss Prot

P36639

UMLS CUI

C0210507

code

C49206