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Floxuridine

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A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04) [ ]

Term info

Label

Floxuridine

Synonyms
  • 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
  • 2'-Deoxy-5-fluorouridine
  • 2-Deoxy-5-fluorouridine
  • 5-FUDR
  • 5-FUdR
  • 5-Fluoro-2'-deoxy-beta-uridine
  • 5-Fluoro-2'-deoxyuridine
  • 5-Fluorodeoxyuridine
  • 5-Fluorouracil Deoxyriboside
  • 5-Fluorouracil deoxyriboside
  • 5-Fluorouridine Deoxyribose
  • FDUR
  • FLOXURIDINE
  • FUDR
  • FUdR
  • Floxuridin
  • Floxuridine
  • Fluorodeoxyuridine
  • Fluorouridine Deoxyribose
  • Fluoruridine Deoxyribose
  • Fluoruridine deoxyribose
  • WR-138720
  • floxuridine
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A drug used in the treatment of cancer. It is a type of antimetabolite.

Accepted Therapeutic Use For

Gastrointestinal adenocarcinoma metastatic to the liver

CAS Registry

50-91-9

CHEBI ID

CHEBI:60761

Chemical Formula

C9H11FN2O5

Display Name

Floxuridine

FDA UNII Code

039LU44I5M

Legacy Concept Name

Floxuridine

NSC Code

27640

Preferred Name

Floxuridine

Semantic Type

Pharmacologic Substance, Nucleic Acid, Nucleoside, or Nucleotide

UMLS CUI

C0016343

code

C504