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Hydroxyurea

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A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04) [ ]

Term info

Label

Hydroxyurea

Synonyms
  • Droxia
  • HYDROXYUREA
  • Hydrea
  • Hydroxycarbamide
  • Hydroxyurea
  • Litalir
  • Onco-Carbide
  • Onco-carbide
  • Oncocarbide
  • Oxeron
  • SQ 1089
  • SQ-1089
  • Syrea
  • WR 83799
  • hydroxyurea
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

An anticancer drug that belongs to the family of drugs called antimetabolites.

Accepted Therapeutic Use For

Chronic Myelogenous Leukemia; Head and Neck Cancer; Malignant Melanoma; Ovarian Carcinoma; Sickle Cell Anemia; Adjuvant in Retroviral Therapy.

CAS Registry

127-07-1

CHEBI ID

CHEBI:44423

Display Name

Hydroxyurea

FDA UNII Code

X6Q56QN5QC

Legacy Concept Name

Hydroxyurea

NSC Code

32065

Preferred Name

Hydroxyurea

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0020402

code

C560

Term relations

Related from:
Chemotherapy_Regimen_Has_Component