Terminology Service for NFDI4Health

Recombinant Interferon

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One of a group of recombinant therapeutic glycoprotein cytokines with antiviral, anti-proliferative, and immunomodulating activities. Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with interferon-specific response elements (ISREs). The resultant proteins mediate many complex effects, ultimately leading to inhibition of viral protein synthesis and cellular growth, alteration of cellular differentiation, interference with oncogene expression, activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity. The production of endogenous interferons is induced in response to foreign agents such as bacteria, viruses and parasites and to tumor cells. [ ]

Term info

Label

Recombinant Interferon

Synonyms
  • Human Leukocyte Interferon
  • Human Lymphoblastoid Interferon
  • Human lymphoblastoid interferon
  • IFN
  • Interferons
  • Recombinant Interferon
Subsets

NCIT_C128784, NCIT_C157711, NCIT_C157712

CAS Registry

9008-1-11

Legacy Concept Name

Therapeutic_Interferon

NSC Code

339140

Preferred Name

Recombinant Interferon

Semantic Type

Pharmacologic Substance, Amino Acid, Peptide, or Protein

UMLS CUI

C1522537

code

C584