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Isotretinoin

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A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. [ ]

Term info

Label

Isotretinoin

Synonyms
  • 13-cRA
  • 13-cis retinoic acid
  • 13-cis-Retinoate
  • 13-cis-Retinoic Acid
  • 13-cis-Vitamin A Acid
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid
  • Absorica
  • Accure
  • Accutane
  • Amnesteem
  • Cistane
  • Claravis
  • ISOTRETINOIN
  • Isotretinoin
  • Isotretinoinum
  • Isotrex
  • Isotrexin
  • Myorisan
  • Neovitamin A
  • Neovitamin A Acid
  • Oratane
  • Retinoicacid-13-cis
  • Ro 4-3780
  • Ro-4-3780
  • Roaccutan
  • Roaccutane
  • Roacutan
  • Sotret
  • ZENATANE
  • cis-Retinoic Acid
  • isotretinoin
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid.

Accepted Therapeutic Use For

Severe recalcitrant nodular acne; psoriasis; cornification disorders; cutaneous T-cell lymphoma; juvenile metastatic neuroblastoma and leukemia

CAS Registry

4759-48-2

CHEBI ID

CHEBI:6067

Chemical Formula

C20H28O2

Display Name

Isotretinoin

FDA UNII Code

EH28UP18IF

Legacy Concept Name

Isotretinoin

NSC Code

329481

Preferred Name

Isotretinoin

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0022265

code

C603