Terminology Service for NFDI4Health

Tubulin Binding Agent TTI-237

Go to external page http://purl.obolibrary.org/obo/NCIT_C61566


A small synthetic molecule of triazolopyrimidine derivative with potential antitumor activity. With a novel mechanism of action distinct from the action of other vinca alkaloid compounds, TTI-237 specifically binds to tubulin at the vinca site, and promotes the polymerization of tubulin into microtubules. TTI-237 stabilizes tubulin and inhibits microtubule disassembly. This results in cell cycle arrest at the G2/M phase, and leading to cell death. [ ]

Term info

Label

Tubulin Binding Agent TTI-237

Synonyms
  • TTI 237
  • TTI-237
  • Tubulin Binding Agent TTI-237
Subsets

NCIT_C128784, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called mitotic inhibitors.

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

Preferred Name

Tubulin Binding Agent TTI-237

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1831611

code

C61566