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Amatuximab

Go to external page http://purl.obolibrary.org/obo/NCIT_C62483

A chimeric IgG1 monoclonal antibody against human mesothelin with potential anti-tumor activity. Amatuximab specifically targets mesothelin, a cell surface glycoprotein involved in cell adhesion and overexpressed on many epithelial-derived cancer cells. Upon binding to the mesothelin antigen, amatuximab triggers an antibody dependent cellular cytotoxicity (ADCC)-mediated host immune response against mesothelin-expressing cells, resulting in cell lysis. [ ]

Term info

Label

Amatuximab

Synonyms
  • AMATUXIMAB
  • Amatuximab
  • Anti-Mesothelin Monoclonal Antibody MORAb-009
  • Immunoglobulin G1, Anti-(mesothelin) (Human-Mouse Monoclonal MORAb-009 Heavy Chain), Disulfide with Human-Mouse Monoclonal MORAb-009 Kappa-Chain, Dimer
  • MORAb-009
  • anti-mesothelin monoclonal antibody MORAb-009
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A monoclonal antibody being studied in the treatment of some types of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Anti-mesothelin monoclonal antibody MORAb-009 binds to mesothelin (a protein that is made by some cancer cells) and stops the cells from dividing.

CAS Registry

931402-35-6

Chemical Formula

C6394H9870N1694O2024S46

Display Name

Amatuximab

FDA UNII Code

6HP0354G04

Has Target

http://purl.obolibrary.org/obo/NCIT_C20887

Legacy Concept Name

Anti-Mesothelin_Monoclonal_Antibody

Preferred Name

Amatuximab

Semantic Type

Amino Acid, Peptide, or Protein, Immunologic Factor

UMLS CUI

C3179481

code

C62483