Terminology Service for NFDI4Health

Hsp90 Inhibitor BIIB021

Go to external page http://purl.obolibrary.org/obo/NCIT_C62517


An orally active inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90, a chaperon protein upregulated in a variety of tumor cells, regulates the folding and degradation of many oncogenic signaling proteins. HSP90 inhibitor BIIB021 specifically blocks active HSP90, thereby inhibiting its chaperon function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival. As a result, CNF2024 has the potential to inhibit the growth of a wide range of cancer cells in both solid tumors and blood-based cancers. [ ]

Term info

Label

Hsp90 Inhibitor BIIB021

Synonyms
  • BIIB-021
  • BIIB021
  • CNF2024
  • Hsp90 Antagonist CNF2024
  • Hsp90 Inhibitor BIIB021
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

CAS Registry

848695-25-0

Chemical Formula

C14H15ClN6O

Display Name

Hsp90 Inhibitor BIIB021

FDA UNII Code

851B9FQ7Q0

Has Target

http://purl.obolibrary.org/obo/NCIT_C17766

Preferred Name

Hsp90 Inhibitor BIIB021

Semantic Type

Pharmacologic Substance

UMLS CUI

C1831929

code

C62517