CDK Inhibitor SNS-032
A small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent causes cytotoxicity and prevents further tumor cell growth. [ ]
Term info
CDK Inhibitor SNS-032
- BMS-387032
- CDK Inhibitor SNS-032
- SNS-032
NCIT_C128784, NCIT_C157711, NCIT_C157712
http://purl.obolibrary.org/obo/NCIT_C25842
SNS-032
488948
488948
CDK Inhibitor SNS-032
Pharmacologic Substance
C1451099
C62523
Term relations
- Antineoplastic Enzyme Inhibitor
- Cyclin-Dependent Kinase Inhibitor
- Chemical_Or_Drug_Has_Physiologic_Effect some Gene Regulation Process
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Enzyme Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Protein Phosphorylation Inhibition
- Chemical_Or_Drug_Affects_Gene_Product some Cyclin-Dependent Kinase