Terminology Service for NFDI4Health

Vintafolide

Go to external page http://purl.obolibrary.org/obo/NCIT_C62525


A water-soluble, folate-receptor-targeted conjugate of folate and the vinca alkaloid desacetylvinblastine monohydrazide (DAVLBH) with potential antineoplastic activity. The folate moiety of vintafolide binds to folic acid receptors on the tumor cell surface and the agent is internalized via folate receptor-mediated endocytosis, delivering the tubulin-binding DAVLBH moiety directly into the tumor cell; DAVLBH binding to tubulin results in the disruption of microtubule assembly-disassembly dynamics, cell cycle arrest, and tumor cell apoptosis. Folic acid receptors are frequently upregulated on the surfaces of many tumor cell types. DAVLBH is a derivative of the natural product vinblastine. [ ]

Term info

Label

Vintafolide

Synonyms
  • EC145
  • Folate-Vinca Alkaloid Conjugate EC145
  • VINTAFOLIDE
  • Vintafolide
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

CAS Registry

742092-03-1

Chemical Formula

C86H109N21O26S2

Display Name

Vintafolide

FDA UNII Code

36O410ZD4I

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

Preferred Name

Vintafolide

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1831870

code

C62525