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Poly (ADP-Ribose) Polymerase Inhibitor

Go to external page http://purl.obolibrary.org/obo/NCIT_C62554

Any substance that inhibits Poly (ADP-Ribose) polymerase, an enzyme involved in detecting DNA single strand breaks and the initiation of DNA repair. Inhibition of Poly (ADP-Ribose) polymerase has direct cytotoxic effects by inhibiting DNA repair and causing cell death. [ ]

Term info

Label

Poly (ADP-Ribose) Polymerase Inhibitor

Synonyms
  • PARP Inhibitor
  • PARP inhibitor
  • Poly (ADP-Ribose) Polymerase Inhibitor
  • Poly(ADP-Ribose) Polymerase Inhibitor
  • poly (ADP-ribose) polymerase inhibitor
Subsets

NCIT_C116978, NCIT_C116977

ALT DEFINITION

A substance that blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. It may cause cancer cells to die. It is a type of targeted therapy.

CHEBI ID

CHEBI:62913

Display Name

PARP Inhibitor

Legacy Concept Name

Poly_ADP-Ribose_Polymerase_Inhibitor

Preferred Name

Poly (ADP-Ribose) Polymerase Inhibitor

Semantic Type

Chemical Viewed Functionally

UMLS CUI

C1882413

code

C62554