Terminology Service for NFDI4Health

5-Fluoro-2-Deoxycytidine

Go to external page http://purl.obolibrary.org/obo/NCIT_C62785


An antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth. [ ]

Term info

Label

5-Fluoro-2-Deoxycytidine

Synonyms
  • 5-FLUORO-2'-DEOXYCYTIDINE
  • 5-Fluoro-2-Deoxycytidine
  • 5-fluoro-2-deoxycytidine
  • Cytidine, 2'-deoxy-5-fluoro-
  • FdCyd
  • Ro 5-1090
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of some types of cancer. It may prevent the growth of tumors by stopping cancer cells from dividing and by killing them. It is a type of antimetabolite.

CAS Registry

10356-76-0

Chemical Formula

C9H12FN3O4

Display Name

5-Fluoro-2-Deoxycytidine

FDA UNII Code

KUA4693H5W

Has Target

http://purl.obolibrary.org/obo/NCIT_C449

Legacy Concept Name

_5-Fluoro-2-Deoxycytidine

NSC Code

48006

Preferred Name

5-Fluoro-2-Deoxycytidine

Semantic Type

Pharmacologic Substance, Nucleic Acid, Nucleoside, or Nucleotide

UMLS CUI

C0049174

code

C62785