5-Fluoro-2-Deoxycytidine
An antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth. [ ]
Term info
5-Fluoro-2-Deoxycytidine
- 5-FLUORO-2'-DEOXYCYTIDINE
- 5-Fluoro-2-Deoxycytidine
- 5-fluoro-2-deoxycytidine
- Cytidine, 2'-deoxy-5-fluoro-
- FdCyd
- Ro 5-1090
NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
A substance being studied in the treatment of some types of cancer. It may prevent the growth of tumors by stopping cancer cells from dividing and by killing them. It is a type of antimetabolite.
10356-76-0
C9H12FN3O4
CTRP, FDA
5-Fluoro-2-Deoxycytidine
KUA4693H5W
http://purl.obolibrary.org/obo/NCIT_C449
_5-Fluoro-2-Deoxycytidine
48006
509184
509184
5-Fluoro-2-Deoxycytidine
Pharmacologic Substance, Nucleic Acid, Nucleoside, or Nucleotide
C0049174
C62785