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Pegdinetanib

Go to external page http://purl.obolibrary.org/obo/NCIT_C62791

A pegylated form of a thermostable and protease resistant peptide targeting human vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic activity. Derived from the 10th type III domain of human fibronectin and one of the natural ligands, pegdinetanib binds to VEGFR-2 and prevents activation of VEGFR-2 by other activating ligands. This may inhibit the growth of new tumor blood vessels. [ ]

Term info

Label

Pegdinetanib

Synonyms
  • Angiocept
  • BMS-844203
  • CT-322
  • PEGDINETANIB
  • Pegdinetanib
  • VEGFR-2 inhibitor CT-322
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A substance being studied in the treatment of cancer. CT-322 may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor and a type of antiangiogenesis agent.

CAS Registry

906450-24-6

Display Name

Pegdinetanib

FDA UNII Code

SSB56T0M0L

Preferred Name

Pegdinetanib

Semantic Type

Pharmacologic Substance

UMLS CUI

C1831965

code

C62791