Oral Ixabepilone
An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at the G2-M phase and leads to apoptosis within fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation provides a more manageable way to administer this agent. [ ]
Term info
Oral Ixabepilone
- Oral Ixabepilone
NCIT_C128784, NCIT_C157711, NCIT_C157712
http://purl.obolibrary.org/obo/NCIT_C17219
Oral_Ixabepilone
CL415081
486610
486610
Oral Ixabepilone
Pharmacologic Substance, Organic Chemical
C63478
Term relations
- Epothilone B Analogue
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Microtubule Process
- Chemical_Or_Drug_Affects_Gene_Product some Tubulin
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Mitosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of G2 to M Transition