Terminology Service for NFDI4Health

Fenretinide Lipid Matrix

Go to external page http://purl.obolibrary.org/obo/NCIT_C63482


An orally bioavailable powder formulation of a synthetic phenylretinamide analogue of retinol with potential chemopreventive and antineoplastic activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types, including those of the colon, breast, prostate, and neuroblastoma. Independent of RAR activation, this agent also modulates gene expression that leads to ceramide-induced, caspase-independent programmed cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species (ROS). Compared to the capsule form, the powder contains a mixture of wheat flour, fats, and sugar that may contribute to the enhanced bioavailability of fenretinide. [ ]

Term info

Label

Fenretinide Lipid Matrix

Synonyms
  • Fenretinide LXS
  • Fenretinide Lipid Matrix
  • Fenretinide Lym-X-Sorb
  • fenretinide LXS
  • fenretinide Lym-X-Sorb
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A powdered form of fenretinide that is being studied in the treatment of neuroblastoma. It may be used by the body more easily than the pill form. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.

Display Name

Fenretinide Lipid Matrix

Has Target

http://purl.obolibrary.org/obo/NCIT_C17532

Legacy Concept Name

Fenretinide_Lipid_Matrix

Preferred Name

Fenretinide Lipid Matrix

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1831747

code

C63482