Oral Fludarabine Phosphate
An oral formulation of the phosphate salt of fludarabine, a synthetic purine nucleoside analogue antimetabolite with antineoplastic activity. Fudarabine is preferentially transported into malignant cells and metabolized by deoxycytidine kinase to its active form, 2-fluoro-ara-ATP; 2-fluoro-ara-ATP competes directly with deoxyadenosine triphosphate (dATP) and inhibits alpha DNA polymerase, RNA reductase, and DNA primase, which may result in inhibition of DNA synthesis and cell death. [ ]
Term info
Oral Fludarabine Phosphate
- Fludara Oral
- Oral Fludarabine Phosphate
NCIT_C128784, NCIT_C157711, NCIT_C157712
Oral_Fludarabine_Phosphate
486428
486428
Oral Fludarabine Phosphate
Pharmacologic Substance, Nucleic Acid, Nucleoside, or Nucleotide
C1831839
C64338