KSP Inhibitor AZD4877
A synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis. Inhibition of KSP results in an inhibition of mitotic spindle assembly, activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, thereby causing cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, AZD4877 may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. [ ]
Term info
KSP Inhibitor AZD4877
- AZD4877
- KSP Inhibitor AZD4877
NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
CTRP
KSP Inhibitor AZD4877
http://purl.obolibrary.org/obo/NCIT_C48872
AZD4877
522717
522717
KSP Inhibitor AZD4877
Pharmacologic Substance, Organic Chemical
C1879525
C64522
Term relations
- Mitotic Kinesin Modulator
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Enzyme Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Affects_Gene_Product some Kinesin-Like Protein KIF11
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Cell Cycle