Riviciclib
A flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Riviciclib selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation. [ ]
Term info
Riviciclib
- Cyclin Dependent Kinase Inhibitor P276
- P-276-00 Free Base
- P276
- P276-00
- RIVICICLIB
- Riviciclib
NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C116977, NCIT_C157711, NCIT_C157712
920113-02-6
CTRP, FDA
Riviciclib
9EK26WE8QN
http://purl.obolibrary.org/obo/NCIT_C17767
P276
529362
529362
Riviciclib
Pharmacologic Substance, Organic Chemical
C1832023
C64762
Term relations
- Antineoplastic Enzyme Inhibitor
- Cyclin-Dependent Kinase Inhibitor
- Chemical_Or_Drug_Has_Mechanism_Of_Action some Enzyme Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Positive Regulation of Apoptosis
- Chemical_Or_Drug_Affects_Gene_Product some Cyclin-Dependent Kinase
- Chemical_Or_Drug_Has_Physiologic_Effect some Negative Regulation of Cell Cycle