Terminology Service for NFDI4Health

E2F1 Pathway Activator ARQ 171

Go to external page http://purl.obolibrary.org/obo/NCIT_C64767


A second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 171 induces the expression of E2F transcription factor 1, thereby activating the E2F1-mediated checkpoint process. E2F1, down-regulated in cancer cells, regulates expression of genes involved in the cell cycle progression from G1 into S phase. The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression. [ ]

Term info

Label

E2F1 Pathway Activator ARQ 171

Synonyms
  • ARQ 171
  • E2F1 Pathway Activator ARQ 171
Subsets

NCIT_C128784, NCIT_C157711, NCIT_C157712

Has Target

http://purl.obolibrary.org/obo/NCIT_C17546

Preferred Name

E2F1 Pathway Activator ARQ 171

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1832018

code

C64767