Terminology Service for NFDI4Health

Verubulin Hydrochloride

Go to external page http://purl.obolibrary.org/obo/NCIT_C64782


The hydrochloride salt form of verubulin, a quinazoline derivative with potential dual antineoplastic activities. Verubulin binds to and inhibits tubulin polymerization and interrupts microtubule formation, resulting in disruption of mitotic spindle assembly, cell cycle arrest in the G2/M phase, and cell death. This agent is not a substrate for several subtypes of multidrug resistance ABC transporters, such as P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1); therefore, it may be useful for treating multidrug resistant (MDR) tumors that express these transporters. In addition, as a vascular disrupting agent (VDA), verubulin appears to disrupt tumor microvasculature specifically, which may result in acute ischemia and massive tumor cell death. [ ]

Term info

Label

Verubulin Hydrochloride

Synonyms
  • Azixa
  • MPC-6827
  • Microtubule Inhibitor MPC-6827
  • N-(4-methoxyphenyl)-n,2-dimethylquinazolin-4-amine Hydrochloride
  • VERUBULIN HYDROCHLORIDE
  • Verubulin Hydrochloride
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712

CAS Registry

917369-31-4

Chemical Formula

C17H17N3O.HCl

Display Name

Verubulin Hydrochloride

FDA UNII Code

33380QZ0QW

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C96747

Has Target

http://purl.obolibrary.org/obo/NCIT_C17219

Preferred Name

Verubulin Hydrochloride

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C1832001

code

C64782