Crolibulin
A small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis. [ ]
Term info
Crolibulin
- CROLIBULIN
- Crolibulin
- EPC2407
- Microtubule Inhibitor EPC2407
NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
1000852-17-4
C18H17BrN4O3
CTRP, FDA
Crolibulin
9ENT43KY91
http://purl.obolibrary.org/obo/NCIT_C17219
EPC2407
536028
536028
Crolibulin
Pharmacologic Substance, Organic Chemical
C1880474
C66938