Terminology Service for NFDI4Health
Multikinase Inhibitor AT9283
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http://purl.obolibrary.org/obo/NCIT_C66947
A small synthetic molecule and aurora kinase (AK) inhibitor with potential antineoplastic activity. AT9283 selectively binds to and inhibits AKs A and B, which are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. Inhibition of these kinases results in an inhibition of cellular division and proliferation in tumor cells that overexpress AKs. [ ]
Term info
Label
Multikinase Inhibitor AT9283
Synonyms
- AT9283
- Aurora kinase inhibitor AT9283
- Multikinase Inhibitor AT9283
Subsets
NCIT_C116978, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712
ALT DEFINITION
A substance being studied in the treatment of some types of cancer. It blocks enzymes (Aurora kinases) involved in cell division and may kill cancer cells. AT9283 is a type of serine/threonine protein kinase inhibitor.
Contributing Source
CTRP
Display Name
Multikinase Inhibitor AT9283
Has Target
http://purl.obolibrary.org/obo/NCIT_C30006
Legacy Concept Name
AT9283
PDQ Closed Trial Search ID
534287
PDQ Open Trial Search ID
534287
Preferred Name
Multikinase Inhibitor AT9283
Semantic Type
Pharmacologic Substance
UMLS CUI
C1879521
code
C66947
Term relations
Subclass of:
- Protein Kinase Inhibitor
- Antineoplastic Enzyme Inhibitor
- Chemical_Or_Drug_Has_Physiologic_Effect some Enzyme Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Inhibition of Cell Proliferation
- Chemical_Or_Drug_Has_Physiologic_Effect some Signal Transduction Inhibition
- Chemical_Or_Drug_Affects_Gene_Product some Aurora Kinase A