Terminology Service for NFDI4Health

Colchicine-Site Binding Agent

Go to external page http://purl.obolibrary.org/obo/NCIT_C67421


An anti-mitotic compound that binds to the beta tubulin subunit at the N-terminal domain (within residues 1-41) and within residues 214-241. Agents binding at the colchicine site produce a conformational change in the protofilament structure which subsequently impairs the polymerization of tubulin dimers and thereby prevents the formation of microtubules. The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, leading to cell cycle arrest and/or apoptosis. [ ]

Term info

Label

Colchicine-Site Binding Agent

Synonyms
  • Colchicine-Site Binding Agent
  • Colchicine-Site Binding Agents
Legacy Concept Name

Colchicine-Site_Binding_Agent

Preferred Name

Colchicine-Site Binding Agent

Semantic Type

Chemical Viewed Functionally

UMLS CUI

C1880116

code

C67421

Term relations

Subclass of: