Terminology Service for NFDI4Health

Mitotic Kinesin Modulator

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A class of compounds that modulate the activity of mitotic kinesins. Mitotic kinesins or microtubule-associated proteins (MAPs) are ATP-powered proteins that convert energy into a mechanical force along the microtubule structure following the hydrolysis of ATP, which occurs during microtubule polymerization. Mitotic kinesins play an essential role in regulating the formation of the mitotic spindle as well as regulating their function. Agents that modulate the activity of kinesins, specifically those that produce inhibitory effects, interfere with mitotic spindle assembly, organization and eventually, chromosome alignment and segregation, thereby inducing mitotic arrest. [ ]

Term info

Label

Mitotic Kinesin Modulator

Synonyms
  • Mitotic Kinesin Modulator
Legacy Concept Name

Mitotic_Kinesin_Modulator

Preferred Name

Mitotic Kinesin Modulator

Semantic Type

Chemical Viewed Functionally

UMLS CUI

C1881871

code

C67440

Term relations

Subclass of: