Terminology Service for NFDI4Health
Complement Component-4
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http://purl.obolibrary.org/obo/NCIT_C70618
Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components. [ ]
Term info
Label
Complement Component-4
Synonyms
- C4
- Complement C4
- Complement Component-4
Subsets
NCIT_C90259, NCIT_C116977, NCIT_C118468, NCIT_C142800, NCIT_C142799
ALT DEFINITION
An early component of the classical and mannose binding lectin (MBL) complement activation pathways. C4 is consumed by proteolysis upon activation of the classical and MBL pathways, but not the alternative pathway. C4 levels are generally low in active immune complex diseases mediated by classical or MBL activation, but not alternative activation, with the canonical example being systemic lupus erythematosus.
Contributing Source
CTRP, NICHD
DesignNote
Human complement component C4 is polymorphic at two loci, C4A and C4B. 13 alleles of C4A and 22 alleles of C4B have been detected. The C4A alleles carry the Rodgers (Rg) blood group antigens while the C4B alleles carry the Childo (Ch) blood group antigens. (SwissProt)
Display Name
Complement Component-4
Has NICHD Parent
http://purl.obolibrary.org/obo/NCIT_C13236
Legacy Concept Name
Complement_Component-4
NICHD Hierarchy Term
Complement C4
Preferred Name
Complement Component-4
Related To Genetic Biomarker
http://purl.obolibrary.org/obo/NCIT_C128859, http://purl.obolibrary.org/obo/NCIT_C128857
Semantic Type
Amino Acid, Peptide, or Protein
UMLS CUI
C0009516
code
C70618