Terminology Service for NFDI4Health
Aurora Kinase Inhibitor SNS-314
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http://purl.obolibrary.org/obo/NCIT_C70655
A synthetic small molecule Aurora kinase (AK) inhibitor with potential antineoplastic activity. Aurora kinase inhibitor SNS-314 selectively binds to and inhibits AKs A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress AKs. AKs are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis. [ ]
Term info
Label
Aurora Kinase Inhibitor SNS-314
Synonyms
- Aurora Kinase Inhibitor SNS-314
- SNS-314
Subsets
NCIT_C116978, NCIT_C128784, NCIT_C116977, NCIT_C157711, NCIT_C157712
Contributing Source
CTRP
Display Name
Aurora Kinase Inhibitor SNS-314
Has Target
http://purl.obolibrary.org/obo/NCIT_C30006
Legacy Concept Name
Aurora_Kinase_Inhibitor_SNS-314
PDQ Closed Trial Search ID
570599
PDQ Open Trial Search ID
570599
Preferred Name
Aurora Kinase Inhibitor SNS-314
Semantic Type
Pharmacologic Substance
UMLS CUI
C2346877
code
C70655
Term relations
Subclass of:
- Antineoplastic Enzyme Inhibitor
- Aurora Kinase Inhibitor
- Chemical_Or_Drug_Has_Physiologic_Effect some Enzyme Inhibition
- Chemical_Or_Drug_Has_Physiologic_Effect some Inhibition of Cell Proliferation
- Chemical_Or_Drug_Has_Physiologic_Effect some Signal Transduction Inhibition
- Chemical_Or_Drug_Affects_Gene_Product some Aurora Kinase A