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Sunitinib

Go to external page http://purl.obolibrary.org/obo/NCIT_C71622

An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. [ ]

Term info

Label

Sunitinib

Synonyms
  • 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
  • SUNITINIB
  • Sunitinib
  • sunitinib
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C116977, NCIT_C157711, NCIT_C157712

ALT DEFINITION

A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). Sunitinib is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.

CAS Registry

557795-19-4

CHEBI ID

CHEBI:38940

Chemical Formula

C22H27FN4O2

Display Name

Sunitinib

FDA UNII Code

V99T50803M

Has Salt Form

http://purl.obolibrary.org/obo/NCIT_C26673

Has Target

http://purl.obolibrary.org/obo/NCIT_C17322, http://purl.obolibrary.org/obo/NCIT_C17328, http://purl.obolibrary.org/obo/NCIT_C26202, http://purl.obolibrary.org/obo/NCIT_C26203, http://purl.obolibrary.org/obo/NCIT_C17975, http://purl.obolibrary.org/obo/NCIT_C18539, http://purl.obolibrary.org/obo/NCIT_C28496

Preferred Name

Sunitinib

Semantic Type

Pharmacologic Substance

UMLS CUI

C1176020

code

C71622