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Alvocidib

Go to external page http://purl.obolibrary.org/obo/NCIT_C74940

The free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. [ ]

Term info

Label

Alvocidib

Synonyms
  • (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one
  • ALVOCIDIB
  • Alvocidib
  • Alvocidib Freebase
  • Flavopiridol
  • alvocidib
  • flavopiridol
Subsets

NCIT_C116978, NCIT_C63923, NCIT_C128784, NCIT_C157711, NCIT_C116977, NCIT_C157712

CAS Registry

146426-40-6

Chemical Formula

C21H20ClNO5

Display Name

Alvocidib

FDA UNII Code

45AD6X575G

Has Salt Form

http://purl.obolibrary.org/obo/NCIT_C1571

Has Target

http://purl.obolibrary.org/obo/NCIT_C17767

Legacy Concept Name

Alvocidib_Freebase

Preferred Name

Alvocidib

Semantic Type

Pharmacologic Substance, Organic Chemical

UMLS CUI

C0174903

code

C74940