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Integrin Alpha-IIb/Beta-3

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Integrin alpha-IIb/beta3 is a protein complex comprised of a heterodimer of integrin alpha 2b and integrin beta 3. This complex is involved in cell adhesion and blood clot formation. [ ]

Term info

Label

Integrin Alpha-IIb/Beta-3

Synonyms
  • Alpha 2b/Beta 3
  • Alpha 2b/Beta 3 Integrin
  • Alpha-IIb/Beta-3
  • Alpha-IIb/Beta-3 Integrin
  • Alpha2b/Beta3
  • Alpha2b/Beta3 Integrin
  • GP IIb/IIIa
  • Glycoprotein IIb/IIIa
  • Integrin Alpha-2b/Beta-3
  • Integrin Alpha-IIb/Beta-3
  • gpIIb/IIIa
Subsets

NCIT_C116977, NCIT_C142800, NCIT_C142799

DesignNote

Integrin Alpha-IIb/Beta3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the amino acid sequence R-G-D in a wide array of ligands and H-H-L-G-G-G-A-K-Q-A-G-D-V in the fibrinogen gamma chain. Following activation, integrin alpha-IIb/beta-3 binds to soluble fibrinogen and catalyzes rapid platelet aggregation. (UniProt)

Display Name

Integrin Alpha-IIb/Beta-3

Legacy Concept Name

Integrin_Alpha-IIb_Beta-3

Preferred Name

Integrin Alpha-IIb/Beta-3

Semantic Type

Amino Acid, Peptide, or Protein

UMLS CUI

C0016011

code

C77161