Terminology Service for NFDI4Health
Transthyretin
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http://purl.obolibrary.org/obo/NCIT_C79964
Transthyretin (147 aa, ~16 kDa) is encoded by the human TTR gene. This protein is involved in both the binding and transport of retinol and thyroxine. [ ]
Term info
Label
Transthyretin
Synonyms
- ATTR
- Prealbumin
- TBPA
- TTR
- Transthyretin
Subsets
NCIT_C116977, NCIT_C142800, NCIT_C142799
Contributing Source
CTRP
DesignNote
Transthyretin is a homotetramer with two thyroxine binding sites. Less than 1% of plasma transthyretin is involved in thyroxine transport, while 40% is in a tight protein-protein complex with the plasma retinol-binding protein (RBP). The formation of the complex with RBP stabilizes the binding of retinol to RBP and decreases the glomerular filtration and renal catabolism of the RBP molecule. (UniProt)
Display Name
Transthyretin
Legacy Concept Name
Transthyretin
OMIM Number
176300
Preferred Name
Transthyretin
Semantic Type
Amino Acid, Peptide, or Protein
Swiss Prot
P02766
UMLS CUI
C0032923
code
C79964
Term relations
Subclass of:
- Transport Protein
- Gene_Product_Encoded_By_Gene some TTR Gene
- Gene_Product_Plays_Role_In_Biological_Process some Transport Process
- Gene_Product_Plays_Role_In_Biological_Process some Intermediary Metabolic Process
- Gene_Product_Has_Associated_Anatomy some Extracellular Space
- Gene_Product_Malfunction_Associated_With_Disease some Amyloidosis