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Talotrexin Ammonium

Go to external page http://purl.obolibrary.org/obo/NCIT_C80159

An ammonium salt of tallotrexin, an analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. [ ]

Term info

Label

Talotrexin Ammonium

Synonyms
  • 2-(((4S)-4-Carboxy-4-((4-(((2,4-diaminopteridin-6-yl)methyl)amino)benzoyl)amino)butyl)carbamoyl)benzoic Acid Monoammonium Salt
  • PT-523
  • PT523
  • TALOTREXIN AMMONIUM
  • Talotrexin Ammonium
Subsets

NCIT_C116978, NCIT_C128784, NCIT_C63923, NCIT_C116977, NCIT_C157711, NCIT_C157712

CAS Registry

648420-92-2

Chemical Formula

C27H27N9O6.H3N

Display Name

Talotrexin Ammonium

FDA UNII Code

686WJT9102

Has Free Acid Or Base Form

http://purl.obolibrary.org/obo/NCIT_C29341

Legacy Concept Name

Talotrexin_Ammonium

NSC Code

712783

Preferred Name

Talotrexin Ammonium

Semantic Type

Pharmacologic Substance

UMLS CUI

C0288639

code

C80159