Terminology Service for NFDI4Health
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Retinoic Acid Agent

Go to external page http://purl.obolibrary.org/obo/NCIT_C804

A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities. A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation. A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization. (NCI04) [ ]

Term info

Label

Retinoic Acid Agent

Synonyms
  • Retinoic Acid Agent
  • Retinoic Acid and Derivatives
  • Retinoic Acids
  • Retinoid
  • Retinoids
  • retinoid
ALT DEFINITION

A nutrient that the body needs in small amounts to function and stay healthy. Retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). Retinoic acid is being studied in the prevention and treatment of other types of cancer.

CHEBI ID

CHEBI:26537

Legacy Concept Name

Retinoic_Acid_Agent

Preferred Name

Retinoic Acid Agent

Semantic Type

Classification

UMLS CUI

C0035339

code

C804